2010 Toyota Sequoia MPG and Fuel Cost
The 2010 Toyota Sequoia is rated 14 to 16 mpg combined across 5 EPA-tested gas versions; the best is the 4.6L 8-cyl · RWD · 6-speed automatic.
EPA fuel economy
2010 Toyota Sequoia · 5 EPA-tested versionsBest EPA rating
16MPG combined
14 city 19 highway
$4,200 a year to fuel
4.6L 8-cyl · RWD · 6-speed automatic
Best version costs $9,000 more in fuel over 5 years vs the average new vehicle (EPA)
Fuel cost: 15,000 miles a year at EPA's $4.47 a gallon (regular gas).
At EPA's price assumptions, fuel costs $4,200 to $4,800 a year.
Every 2010 Sequoia version
EPA's ratings for each version it tested. Fuel cost is EPA's estimate for 15,000 miles a year at its current prices.
| Version | Combined | City / Hwy | Fuel / year |
|---|---|---|---|
4.6L 8-cyl · RWD · 6-speed automatic Best
EPA listing: Sequoia 2WD |
16 mpg | 14 / 19 | $4,200 |
4.6L 8-cyl · Part-time 4WD · 6-speed automatic
EPA listing: Sequoia 4WD |
15 mpg | 13 / 18 | $4,450 |
5.7L 8-cyl · Part-time 4WD · 6-speed automatic
EPA listing: Sequoia 4WD |
15 mpg | 13 / 18 | $4,450 |
5.7L 8-cyl · RWD · 6-speed automatic
EPA listing: Sequoia 2WD |
15 mpg | 14 / 19 | $4,450 |
5.7L 8-cyl · Part-time 4WD · 6-speed automatic · Flex-fuel (E85)
EPA listing: Sequoia 4WD FFV · Flex-fuel (E85) |
14 mpg | 13 / 18 | $4,800 |
Fuel cost at your prices
EPA's annual cost uses 15,000 miles a year, 55% city driving and its current prices: $4.47 a gallon for regular gas. Change the numbers to match your driving.
| Version | Per year | 5 years |
|---|---|---|
4.6L 8-cyl · RWD · 6-speed automatic | $4,191 | $20,953 |
4.6L 8-cyl · Part-time 4WD · 6-speed automatic | $4,470 | $22,350 |
5.7L 8-cyl · Part-time 4WD · 6-speed automatic | $4,470 | $22,350 |
5.7L 8-cyl · RWD · 6-speed automatic | $4,470 | $22,350 |
5.7L 8-cyl · Part-time 4WD · 6-speed automatic · Flex-fuel (E85) | $4,789 | $23,946 |
At the default settings the results match EPA's annual cost before EPA rounds it to the nearest $50.
Toyota Sequoia MPG by model year
The best-rated version in each model year; the highlighted year is this page. Gas: 15 to 16 mpg (2010 to 2022); highest in 2010. Hybrid: 22 mpg (2023 to 2026).
- Best gas version
- Best hybrid version
2010: gas 16 mpg · hybrid not offeredTap or drag across the chart for other years.
Show as a table
| Model year | Best gas version | Best hybrid version |
|---|---|---|
| 2010 | 16 | – |
| 2011 | 16 | – |
| 2012 | 16 | – |
| 2013 | 15 | – |
| 2014 | 15 | – |
| 2015 | 15 | – |
| 2016 | 15 | – |
| 2017 | 15 | – |
| 2018 | 15 | – |
| 2019 | 15 | – |
| 2020 | 15 | – |
| 2021 | 15 | – |
| 2022 | 15 | – |
| 2023 | – | 22 |
| 2024 | – | 22 |
| 2025 | – | 22 |
| 2026 | – | 22 |
Every Sequoia year's ratings in one table
How the 2010 Sequoia compares
2010 full-size SUVs covered on this site, ranked by their best combined rating. Fuel cost is for each model's cheapest version to run, at EPA's prices.
| 2010 model | Best combined | Best gas | Fuel / year |
|---|---|---|---|
Best: hybrid |
22 mpg | 17 mpg | $3,050 |
Best: hybrid |
22 mpg | 17 mpg | $3,050 |
Best: gas |
17 mpg | 17 mpg | $3,950 |
Best: gas |
16 mpg | 16 mpg | $4,200 |
Toyota Sequoia This page Best: gas |
16 mpg | 16 mpg | $4,200 |
2010 Sequoia recalls and complaints
Questions
Does 4WD lower the 2010 Toyota Sequoia's gas mileage?
Sometimes. On versions that differ only in drive, the gap ranges from 0 to 1 mpg combined: the 4.6L 8-cyl gets 16 mpg combined with two-wheel drive and 15 with 4WD.
Does the 2010 Toyota Sequoia need premium gas?
No. EPA lists every 2010 Toyota Sequoia version on regular gasoline.
Sources and method
- US EPA and Department of Energy fuel economy data (fueleconomy.gov), file dated Sep 29, 2026.
- EPA fuel price assumptions: regular $4.47, midgrade $5.07, premium $5.48, diesel $6.38 a gallon; electricity $0.15 per kWh.
- Recall and complaint counts: NHTSA recall file dated Oct 2, 2026 and complaint file dated Oct 2, 2026.
Ratings are EPA estimates. Real-world mileage depends on how, where and in what weather you drive. How we build these pages. Spotted an error? Tell us.