2021 Toyota Sequoia MPG and Fuel Cost
The 2021 Toyota Sequoia is rated 14 to 15 mpg combined across 2 EPA-tested gas versions; the best is the 5.7L 8-cyl · RWD · 6-speed automatic.
EPA fuel economy
2021 Toyota Sequoia · 2 EPA-tested versionsBest EPA rating
15MPG combined
13 city 17 highway
$4,150 a year to fuel
5.7L 8-cyl · RWD · 6-speed automatic
Best version costs $9,750 more in fuel over 5 years vs the average new vehicle (EPA)
Fuel cost: 15,000 miles a year at EPA's $4.00 a gallon (regular gas).
At EPA's price assumptions, fuel costs $4,150 to $4,450 a year. Ratings for the best versions are unchanged from 2020.
Every 2021 Sequoia version
EPA's ratings for each version it tested. Fuel cost is EPA's estimate for 15,000 miles a year at its current prices.
| Version | Combined | City / Hwy | Fuel / year |
|---|---|---|---|
5.7L 8-cyl · RWD · 6-speed automatic Best
EPA listing: Sequoia 2WD |
15 mpg | 13 / 17 | $4,150 |
5.7L 8-cyl · Part-time 4WD · 6-speed automatic
EPA listing: Sequoia 4WD |
14 mpg | 13 / 17 | $4,450 |
Fuel cost at your prices
EPA's annual cost uses 15,000 miles a year, 55% city driving and its current prices: $4.00 a gallon for regular gas. Change the numbers to match your driving.
| Version | Per year | 5 years |
|---|---|---|
5.7L 8-cyl · RWD · 6-speed automatic | $4,000 | $20,000 |
5.7L 8-cyl · Part-time 4WD · 6-speed automatic | $4,286 | $21,429 |
At the default settings the results match EPA's annual cost before EPA rounds it to the nearest $50.
Toyota Sequoia MPG by model year
The best-rated version in each model year; the highlighted year is this page. Gas: 15 to 16 mpg (2010 to 2022); highest in 2010. Hybrid: 22 mpg (2023 to 2026).
- Best gas version
- Best hybrid version
2021: gas 15 mpg · hybrid not offeredTap or drag across the chart for other years.
Show as a table
| Model year | Best gas version | Best hybrid version |
|---|---|---|
| 2010 | 16 | – |
| 2011 | 16 | – |
| 2012 | 16 | – |
| 2013 | 15 | – |
| 2014 | 15 | – |
| 2015 | 15 | – |
| 2016 | 15 | – |
| 2017 | 15 | – |
| 2018 | 15 | – |
| 2019 | 15 | – |
| 2020 | 15 | – |
| 2021 | 15 | – |
| 2022 | 15 | – |
| 2023 | – | 22 |
| 2024 | – | 22 |
| 2025 | – | 22 |
| 2026 | – | 22 |
Every Sequoia year's ratings in one table
How the 2021 Sequoia compares
2021 full-size SUVs covered on this site, ranked by their best combined rating. Fuel cost is for each model's cheapest version to run, at EPA's prices.
| 2021 model | Best combined | Best gas | Fuel / year |
|---|---|---|---|
Best: diesel |
24 mpg | 18 mpg | $3,450 |
Best: diesel |
23 mpg | 18 mpg | $3,450 |
Best: diesel |
23 mpg | 18 mpg | $3,450 |
Best: gas |
19 mpg | 19 mpg | $3,300 |
Toyota Sequoia This page Best: gas |
15 mpg | 15 mpg | $4,150 |
2021 Sequoia recalls and complaints
Questions
Does 4WD lower the 2021 Toyota Sequoia's gas mileage?
Yes. On versions that differ only in drive, 4WD lowers the combined rating by 1 mpg: the 5.7L 8-cyl gets 15 mpg combined with two-wheel drive and 14 with 4WD.
Does the 2021 Toyota Sequoia need premium gas?
No. EPA lists every 2021 Toyota Sequoia version on regular gasoline.
How does the 2021 Sequoia's MPG compare with the 2020?
For 2021, the best gas version is rated 15 mpg, the same as the year before.
Sources and method
- US EPA and Department of Energy fuel economy data (fueleconomy.gov), file dated Nov 4, 2026.
- EPA fuel price assumptions: regular $4.00, midgrade $4.61, premium $5.01, diesel $6.13 a gallon; electricity $0.15 per kWh.
- Recall and complaint counts: NHTSA recall file dated Nov 12, 2026 and complaint file dated Nov 11, 2026.
Ratings are EPA estimates. Real-world mileage depends on how, where and in what weather you drive. How we build these pages. Spotted an error? Tell us.