Model Years

2021 Toyota Sienna MPG and Fuel Cost

Every 2021 Toyota Sienna is a hybrid, rated 35 to 36 mpg combined across 2 versions.

EPA fuel economy

2021 Toyota Sienna · 2 EPA-tested versions

Best EPA rating

36MPG combined

36 city 36 highway

$1,750 a year to fuel

Fuel economy score8/10

2.5L 4-cyl hybrid · FWD · CVT

Best version saves $2,250 in fuel over 5 years vs the average new vehicle (EPA)

Fuel cost: 15,000 miles a year at EPA's $4.00 a gallon (regular gas).

Data: US EPA, fueleconomy.govUpdated

At EPA's price assumptions, fuel costs $1,750 to $1,800 a year. Every 2021 Sienna is a hybrid; the 2020 also came with gas engines.

More complaints than most Sienna years

The 2021 drew 97 owner complaints in its first three years, against about 52 for a typical Sienna year: 1.8 times as many. It is not a year to avoid, which takes at least twice the typical count and at least 50 complaints.

Years to avoid: 2011; best years: 2018 and 2019. Based on owner complaints, not adjusted for sales.

Every Sienna year rankedThe 2021 Sienna's recalls and problems

Every 2021 Sienna version

EPA's ratings for each version it tested. Fuel cost is EPA's estimate for 15,000 miles a year at its current prices.

VersionCombinedCity / HwyFuel / year
2.5L 4-cyl hybrid · FWD · CVT Best
EPA listing: Sienna Hybrid 2WD
36 mpg 36 / 36 $1,750
2.5L 4-cyl hybrid · AWD · CVT
EPA listing: Sienna Hybrid AWD
35 mpg 35 / 36 $1,800

Fuel cost at your prices

EPA's annual cost uses 15,000 miles a year, 55% city driving and its current prices: $4.00 a gallon for regular gas. Change the numbers to match your driving.

VersionPer yearPer month5 years
2.5L 4-cyl hybrid · FWD · CVT
$1,667$139$8,333
2.5L 4-cyl hybrid · AWD · CVT
$1,714$143$8,571

At the default settings the results match EPA's annual cost before EPA rounds it to the nearest $50.

Toyota Sienna MPG by model year

The best-rated version in each model year; the highlighted year is this page. Gas: 19 to 22 mpg (2010 to 2020); highest in 2017. Hybrid: 36 mpg (2021 to 2026).

  • Best gas version
  • Best hybrid version

2021: gas not offered · hybrid 36 mpg

Show as a table
Toyota Sienna best combined mpg by model year
Model yearBest gas versionBest hybrid version
201019–
201121–
201221–
201321–
201421–
201521–
201621–
201722–
201822–
201922–
202021–
2021–36
2022–36
2023–36
2024–36
2025–36
2026–36

How the 2021 Sienna compares

2021 minivans covered on this site, ranked by their best combined rating. Fuel cost is for each model's cheapest version to run, at EPA's prices.

2021 modelBest combinedBest gasFuel / year
Toyota Sienna This page
Best: hybrid
36 mpg–$1,750
Best: gas
22 mpg22 mpg$2,850
Best: gas
22 mpg22 mpg$2,850

2021 Sienna recalls and complaints

NHTSA lists 4 safety recalls and 210 owner complaints for the 2021 Sienna.

Owners most often describe unintended acceleration (24 complaints, 11%), then jerking or harsh shifting (21). NHTSA's overall crash rating: 5 stars.

See the 2021 Sienna recalls and problems

Questions

Does AWD lower the 2021 Toyota Sienna's gas mileage?

Yes. On versions that differ only in drive, AWD lowers the combined rating by 1 mpg: the 2.5L 4-cyl hybrid gets 36 mpg combined with front-wheel drive and 35 with AWD.

Does the 2021 Toyota Sienna need premium gas?

No. EPA lists every 2021 Toyota Sienna version on regular gasoline.

Sources and method

  • US EPA and Department of Energy fuel economy data (fueleconomy.gov), file dated Nov 4, 2026.
  • EPA fuel price assumptions: regular $4.00, midgrade $4.61, premium $5.01, diesel $6.13 a gallon; electricity $0.15 per kWh.
  • Recall and complaint counts: NHTSA recall file dated Nov 12, 2026 and complaint file dated Nov 11, 2026.

Ratings are EPA estimates. Real-world mileage depends on how, where and in what weather you drive. How we build these pages. Spotted an error? Tell us.